2021 LIFETIME ACHIEVEMENT HONOREE
DR. MICHAEL LEVINE
Dr. Michael A. Levine is Chief Emeritus of Endocrinology and Diabetes and Director of the Center for Bone Health at The Children’s Hospital of Philadelphia. Dr. Levine holds the Lester Baker Endowed Chair and is Professor Emeritus of Pediatrics and Medicine at the University of Pennsylvania Perelman School of Medicine.
Dr. Levine completed his clinical training at the Johns Hopkins University School of Medicine and took dual fellowship training in Endocrinology and Genetics at the National Institutes of Health. His research interests focus on the genetic basis of endocrine signaling defects. His primary clinical interests are endocrine diseases that affect bone and mineral metabolism, particularly osteoporosis, primary hyperparathyroidism, and hypoparathyroidism. Dr. Levine has an active laboratory research program that complements and extends his clinical studies. He has identified and characterized the molecular basis of various inherited disorders of mineral metabolism, including familial hypoparathyroidism, pseudohypoparathyroidism, the McCune Albright syndrome, and novel forms of vitamin D dependent rickets.
Dr. Levine is a member of numerous professional societies, including the American Society for Bone and Mineral Research, American Society for Clinical Investigation, Association of American Physicians, the American Pediatric Society, and the Johns Hopkins Society of Scholars, and has received awards that include the Distinguished Endocrinology Award from the American College of Endocrinology; the Frederic C. Bartter Award from the American Society of Bone and Mineral Research; the International Award from the European Society for Pediatric Endocrinology; and the inaugural Senior Investigator Award from the Pediatric Endocrine Society.
2021 VISIONARY HONOREE
DR. LOURDES IBANEZ
Dr. Ibáñez is a pediatric endocrinologist at Sant Joan de Déu Barcelona Hospital and Chairman of Pediatrics. She is also Chair of Clinical Research in Endocrinology at the University of Barcelona, Spain, director of the Fellowship Program in Pediatric Endocrinology & Diabetes, and Chair of the Spanish Working Group in children born small-for-gestational-age (SGA) and of the Pediatric Adolescent Gynecology Working Group at the European Society for Pediatric Endocrinology.
She has prospectively followed cohorts of individuals born either appropriate-for-gestational-age or SGA since birth through adolescence focusing on endocrine-metabolic markers, body composition, abdominal fat distribution and their association with the pattern of postnatal catch-up in height and weight. Dr. Ibáñez is a worldwide leader in the field of polycystic ovary syndrome and pioneered the use of combined, low-dose insulin sensitization for the treatment of the disease - a novel therapeutic approach directed to the pathophysiology of the disorder.
2021 DR. ROBERT BLIZZARD FOUNDER'S AWARD
DR. SALLY RADOVICK
Sally Radovick, MD, is the Henry Rutgers Term Chair and Professor of Pediatrics and Senior Associate Dean for Clinical and Translational Research at Rutgers-Robert Wood Johnson Medical School. Prior to this position, she was the Division Director of Pediatric Endocrinology and the Vice-Chair for Research in the Department of Pediatrics at Johns Hopkins University School of Medicine. She received her medical degree from Northeastern Ohio Universities College of Medicine, completed her residency in Pediatrics at Case Western Reserve University, and her fellowship in Pediatric Endocrinology at the National Institutes of Health (NIH).
Dr. Radovick is a specialist in growth and development and pubertal disorders in children. Her research is focused on determining the regulation of the gonadotropin-releasing hormone (GnRH) gene, which has a central role in controlling the onset of puberty. Her group was the first to generate GnRH-expressing neuronal cell-lines and in vitro map the cellular regulation of this critical gene by growth factors that have increased knowledge of the relationship between growth, puberty, and nutrition. She has developed genetically modified mouse models to elucidate mechanisms of in vivo regulation of GnRH secretion in response to neuroendocrine and growth factor stimulation and sex steroid feedback regulation. Of particular interest has been to determine the roles of neurotransmitter/hormone receptors in mediating the increase in GnRH secretion to adult levels at puberty, which results in the attainment of fertility.
These studies will provide insights into pubertal disorders, PCOS, as well as provide future therapies for infertility. With recent evidence that implicates the neuroendocrine protein, kisspeptin, responsible for the pubertal onset and reproductive cycling, with obesity and metabolism, Dr. Radovick has begun to explore novel roles for peripheral kisspeptins in the control of metabolic homeostasis. The other major research area has been to characterize the transcription factors important for normal pituitary development. Her initial studies provided the first genetic mechanism of a child with short stature due to hypopituitarism; this involved a mutation in the Pit-1 gene necessary for pituitary cell lineage determination and differentiation. She has described the mechanisms by which novel mutations in other pituitary-specific transcription factors are responsible for pituitary hormone deficiencies. She is the curator of a tissue repository for patients with hypopituitarism. The NIH has continuously supported these studies since 1992 and currently includes an R01 to determine the role of sex steroids in puberty and reproductive cycling and a U01 collaborative agreement with investigators at the NIH Clinical Center to determine the genetics of short stature. She has served on numerous study sections and is the chair of the Integrative and Clinical Endocrine and Reproduction (ICER) study section.
Dr. Radovick has authored or co-authored more than 100 peer-reviewed scientific publications and has been invited to write a dozen book chapters in her field. She is an author of “Puberty in the female and its disorders” in Sperling’s textbook, Pediatric Endocrinology, and “Normal and aberrant growth” in Williams Textbook of Endocrinology. She serves as the Associate Editor of Pediatric Endocrinology, and Editor of ‘Pituitary’ and the Editor in “Current Opinion in Pediatric Endocrinology.’
Dr. Radovick served as the President of the Pediatric Endocrine Society, the Chair of the Research Council, a Council member, and Chair of the Drug and Therapeutics Committee. She was also a member of the Guidelines Committee and the Finance Committee of the Endocrine Society. She is a co-author of the AACE Growth Hormone Guidelines.